Posts Tagged cancer clinical trials

Of Mice and Women: Investigating the Breast Cancer Virus

By Vera Gruessner

Dr. Kathleen Ruddy

Dr. Kathleen Ruddy

Have you heard about the breast cancer virus in mice? There is significant evidence that this virus is linked to human breast cancers. Dr. Kathleen T. Ruddy, a New Jersey-based breast cancer surgeon and Founder of the Breast Health and Healing Foundation, released her executive summary about her soon-to-be-published book “Of Mice and Women:  Unraveling the Mystery of the Breast Cancer Virus.” By June 2015, the book will be published and available in both print and digital formats. To learn more about the upcoming book, you can read the executive summary on the Breast Health and Healing website by clicking here.

In your free time, take a minute to download the executive summary (which is completely free) and share on your social networks! Let your close ones know about the innovative and intriguing book. Over the last eight years, Dr. Kathleen Ruddy wrote and revised this book and is now ready to finish publishing it in paper and electronic formats. Want to know the best part of it all? The digital version will be free to the public at large!

Of Mice and Women

Of Mice and Women (new book)

Did you know that 40 percent of human breast cancers have gene sequences that are analogous to a retrovirus known to cause breast cancer in mice? The retrovirus found in mice is called the mouse mammary tumor virus. Further research on the breast cancer virus is necessary to determine strategies that would prevent this serious medical condition. The researchers Drs. Pogo, Etkind, and Melena have spent decades studying the Pink Virus and its role in human breast cancer.

If we can prove that a virus causes up to 40 percent of human breast cancers, the scientific community can work toward creating a vaccine that would prevent this disease in men and women around the world. This would be an amazing opportunity to eradicate the disease once and for all!

Does the human mammary tumor virus cause breast cancer in women? If so, we need to develop vaccines that can prevent the disease.

Any and all donations that the Breast Health and Healing Foundation gains from the release of the executive summary and the book will be put toward funding the full-length documentary film, “A Pox On Us,” co-produced with Soap Box Media. The profits from the film will be used to directly fund research on the breast cancer virus.

We hope the executive summary and the book will spread like wildfire through the breast cancer community. To achieve this goal, we need your help! Please share it on Facebook. Share it on Twitter. Share it on Google+. Share it on LinkedIn. Let your friends and family know about this revolutionary work!

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The Breast Cancer Vaccine – Curing Cancer Through Prevention

by Vera Viner

Have you seen breast cancer try to take your life and those around you? Have you feared that your daughter, mother, wife, or sister may be diagnosed with this disease? Wouldn’t you do anything you could to prevent breast cancer from taking the lives of your loved ones?

As luck would have it, there might be something in the works right now that could potentially prevent breast cancer in 95 percent of cases. That’s right, 95 percent! Dr. Vincent Tuohy of the Cleveland Clinic and his team designed a breast cancer vaccine. The vaccine was found to prevent the disease in 100 percent of the mice tested.

Dr. Vincent Tuohy

Dr. Vincent Tuohy

The original research including animal models was published in the Nature Medicine journal in June 2010. Tuohy’s team from the Cleveland Clinic’s Lerner Research Institute used the compound alpha-lactalbumin as the main property of the breast cancer vaccine. It was found to both prevent tumor formation AND slow down the growth of existing tumors.

Essentially, the study used a control group of mice that were injected with a vaccine without alpha-lactalbumin and an experimental group that was injected with a vaccine containing the relevant compound. All of the mice in the experimental group did not develop breast cancer despite the fact that both groups of mice were genetically predisposed to the disease. The mice in the control group did develop tumors.

“We believe that this vaccine will someday be used to prevent breast cancer in adult women in the same way that vaccines have prevented many childhood diseases,” Dr. Vincent Tuohy stated in a press release. “If it works in humans the way it works in mice, this will be monumental. We could eliminate breast cancer.”

The next steps in this research were clear: find the funding necessary to begin Phase I trials to determine whether the vaccine is safe to use in women. While it was definitely an uphill battle and many common revenue streams for this innovative research declined to help, Dr. Vincent Tuohy was able to gather enough funding to begin the next stage of clinical study at the end of 2013. While the Susan G. Komen Foundation and some other organizations refused funding, there were some smaller grassroots campaigns that helped push forward this research. For instance, Brakes for Breast Cancer, a nonprofit dependent on the proceedings from a handful of auto repair shops, presented Dr. Tuohy with a check for $32,848.84 in February of 2013.

Cleveland Clinic Innovations has created a spin-off company after securing all of the funding called Shield Biotech. The company will continue to improve upon the preventive breast cancer vaccine. Shield Biotech will be finishing preclinical development and seeking FDA permission to begin testing the vaccine as an investigational new drug in human clinical trials.

Phase I clinical trials are expected to begin within the next two years. It will take approximately three years to complete Phase I studies. The Phase IA trial will follow patients with triple-negative breast cancer who have undergone surgery, chemotherapy, and/or radiation treatment.




During this trial, the researchers will be determining the proper dosage and frequency of the vaccine necessary to ensure the highest immune response for preventing breast cancer development.

Phase IB trials will follow the reactions to the vaccine in healthy women who are at high risk for breast cancer and have chosen to undergo bilateral mastectomy to lower their risk. In this trial, the breast tissue specifically will be studied to determine how the vaccine affects the cancer-free cells.

These initial trials are meant to establish the safety of the vaccine and find the best immune response with regard to dosage. Patients will begin enrollment in the trial starting in 2015.

If you hope to help put a stop to breast cancer and ensure future generations of women do not need to suffer through this disease, please support Dr. Vincent Tuohy’s research on the first preventive breast cancer vaccine.

If you would like to read more about this vaccine click HERE for an article from



Vera Viner is experienced in social media marketing, blog writing, email marketing, and healthcare writing and editing. She is a co-author of a blog that won the “Empowered Doctor Top Cancer Blog” recognition. She has also written an ebook called “The Pure Cure: Cancer Prevention at its Best.” Through proper online channels, Vera gained a following of more than 2,000 businesses and individuals for the Breast Health and Healing Foundation and was able to quadruple the following of an additional client. If you’d like to contact the author, her email is

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Donate Your Data – Share your Cancer Story to Help Yourself While Helping Others

By Sarah Stanley

A decade ago, Internet entrepreneur Marty Tenenbaum was diagnosed with melanoma. He visited several local oncologists, but each doctor recommended a different treatment strategy. With no clear solution, he decided to enroll in a clinical trial that was testing a melanoma vaccine.

The vaccine failed the trial. But, for reasons unknown, it saved Tenenbaum’s life.

Inspired by the difficulty of navigating his options, and the need for better ways to figure out which treatments will work for which patients, Tenenbaum founded Cancer Commons—the first & only open access nonprofit collecting and learning from real patient experiences to give patients the information they need.

Please watch this short video to learn more about Donating Your Data




“Everyone who has been diagnosed with cancer has felt the fright and anguish of having to make life and death decisions without adequate information, data, or time,” Tenenbaum says. “I vowed to do something to spare patients from this agony.”

To support this mission, Cancer Commons has now launched its new Donate Your Data (DYD) Program, an online registry that empowers people with cancer to anonymously share their cancer experiences to advance research and, in return, inform their own clinical care.

Through DYD, each patient records and updates information about his or her cancer experience in a private profile. This information may include stage, treatments, molecular test results, treatment responses, side effects, and more. All data will be de-identified and made freely available, giving doctors, researchers, and patients themselves an unprecedented resource to determine the best approaches to cancer care, according to each patient’s unique clinical history.


Donate Your Data Dashboards from Cancer Commons

Donate Your Data Dashboards from Cancer Commons

Based on the data they provide, patients receive customized news feeds and alerts to relevant clinical studies and trials, reports on any research that uses their data, and notifications concerning important research findings, all delivered through each patient’s personal DYD dashboard. Each patient can graphically track his or her cancer journey on a timeline, and will be able to selectively share it with physicians and other patients.






DYD does not focus solely on figuring out which treatments are most effective at shrinking or eradicating tumors for which patients. DYD aims to capture information on how patients approach every aspect of their cancer journey—including dealing with side effects and overall well-being—so that patients can learn from similar patients about what might work best for them.

For now, DYD is available only to lung cancer and melanoma patients, but Cancer Commons will soon be expanding to cover most cancers. If you have or have had melanoma or lung cancer, please consider joining Cancer Commons in making the dream of personalized cancer treatment a reality for everyone. Donate Your Data now.

For more information, visit Follow Cancer Commons on Facebook and Twitter.

Sarah Stanley is Associate Editor at Cancer Commons, where she helps translate cancer research into useful insights for patients.


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CureLauncher – Personalized Clinical Trial Matching


CureLauncher gives you the power and the support to make a life changing decision.  Warm, compassionate, and experienced relationship managers will guide you through the process of finding a new treatment.  Taking control and knowing your options opens up a whole new world of hope.  Visit CureLauncher to get started on a life changing quest! CureLauncher can help connect you with clinical trials in your area.


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Click on the banner above to learn more about CureLauncher

CureLauncher – Information is Empowerment! – Testimonial 

By Barb  Hollingsworth, guest blogger

Over the holidays of 2012, I knew I wasn’t feeling myself but it wasn’t until I had jaundiced two days after Christmas that I knew it was time to do something about it.  Upon arrival at the Emergency Room, I was quickly rushed through to be seen by a Doctor who immediately ordered a CT scan of my abdomen.  Several hours later I heard the words that would instill fear in the toughest of men – that there was a “mass” in my Pancreas.  The next morning I was sent to surgery to have a stent placed in my bile duct and a biopsy of the mass was taken. Two days later it was confirmed that I have Pancreatic Cancer.  The tumor was nearly 5cm in size in the head of my Pancreas and was quite aggressive.  I met with the Oncologist prior to being discharged from the hospital where I was left feeling there was absolutely no hope for a better tomorrow for me. 


I have always been a strong woman and after the initial shock and disbelief that I was likely facing the end of my days, that fight in me started to return. I was not convinced that this was the end and I just knew that dying was not an option for me! So I started researching every possible avenue of information about Pancreatic Cancer and Cancer in General.  I reached out to my family and friends on social media where the compassion, love and support I receive is astounding! Through them and the Cancer Center where I started chemotherapy treatments, I kept hearing about Clinical Trials. I had a basic knowledge of clinical trials only and was afraid to deter from a “proven” method of treatment.


I soon realized that information is empowerment and that most “proven” treatment methods used today were developed and recognized because of Clinical Trials. The very chemotherapy regiment I am on was founded just a few short years ago in Clinical Trials. That’s when I knew I had to change my thinking and participate – if not to cure myself, but to help find a cure for future generations.


One day, a very dear friend recommended I contact CureLauncher since my Oncologist had not found any Clinical Trials that I would qualify for. Amy contacted me the very same day I requested information from them and went to work right away to search for a match to a Clinical Trial for me. Within days she had located several options for me. I found out in the mean time that my treatments were working so well that my tumor had gone from “unresectable” to virtually “undetectable” on the CT scans! This meant I no longer qualified for the Clinical Trials and was unable to participate.  I am in remission and looking forward to a long healthy future – and I know that somewhere, some people faced with the same “death sentence” that I was – took part in the Clinical Trials that ultimately led to my own cure! I can’t say enough about CureLauncher.


 If you have been diagnosed with any form of cancer, take charge of your future and remember – information is EMPOWERMENT!


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